PROTEASOMAL PROTEOLYSIS Meaning and
Definition
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Proteasomal proteolysis refers to the process by which proteins are broken down or degraded within cells by the action of the proteasome. The proteasome is a large protein complex found in the cytoplasm and nucleus of eukaryotic cells, responsible for the controlled degradation of proteins that are no longer needed or have become damaged.
During proteasomal proteolysis, proteins are marked for degradation by the addition of a small protein called ubiquitin. The ubiquitinated proteins are recognized by the proteasome, which binds to them and unfolds them, allowing entry into its inner chamber where the degradation takes place. Within the proteasome, the proteins are subjected to the action of proteases, which cleave the proteins into smaller peptide fragments.
The resulting peptide fragments can then be further processed and recycled for the synthesis of new proteins. Proteasomal proteolysis plays a critical role in numerous cellular processes, including the regulation of protein levels, the removal of misfolded or damaged proteins, and the control of cell cycle progression.
Proteasomes are essential for maintaining cellular homeostasis and are implicated in a wide range of diseases, including cancer and neurodegenerative disorders. The dysregulation of proteasomal proteolysis can lead to the accumulation of abnormal proteins, resulting in cellular dysfunction and disease pathogenesis. Therefore, studying proteasomal proteolysis and developing strategies to modulate its activity are important areas of research with potential therapeutic implications.
Common Misspellings for PROTEASOMAL PROTEOLYSIS
- oroteasomal proteolysis
- lroteasomal proteolysis
- 0roteasomal proteolysis
- peoteasomal proteolysis
- pdoteasomal proteolysis
- pfoteasomal proteolysis
- ptoteasomal proteolysis
- p5oteasomal proteolysis
- p4oteasomal proteolysis
- priteasomal proteolysis
- prkteasomal proteolysis
- prlteasomal proteolysis
- prpteasomal proteolysis
- pr0teasomal proteolysis
- pr9teasomal proteolysis
- proreasomal proteolysis
- profeasomal proteolysis
- progeasomal proteolysis
- proyeasomal proteolysis
- pro6easomal proteolysis
Etymology of PROTEASOMAL PROTEOLYSIS
The term "proteasomal proteolysis" can be broken down into two parts: "proteasomal" and "proteolysis".
1. Proteasomal: The word "proteasomal" is derived from the noun "proteasome". The term "proteasome" was coined by the researchers Etlinger and Goldberg in 1988. It combines the word "protein" (referring to the molecules it degrades) with the suffix "-some", which denotes a subcellular structure or particle. The proteasome is a large protein complex found in cells responsible for degrading and recycling proteins that are no longer needed or are damaged.
2. Proteolysis: The word "proteolysis" is derived from the noun "protease".
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