PROTEASOMAL DEGRADATION Meaning and
Definition
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Proteasomal degradation refers to a fundamental mechanism within cells that regulates protein turnover and maintains cellular homeostasis. It is a process by which proteins are selectively targeted for degradation by the proteasome, a large protein complex found in the cytoplasm and nucleus of eukaryotic cells. The proteasome acts as a molecular machine that recognizes and eliminates unwanted or damaged proteins.
During proteasomal degradation, specific proteins are marked for destruction by the covalent attachment of a small protein called ubiquitin. This process, known as ubiquitination, involves a cascade of enzymatic reactions that ultimately leads to the conjugation of ubiquitin molecules to the target protein. Once a protein is polyubiquitinated, it is recognized and bound by the proteasome, which then unfolds the protein and cleaves it into smaller peptide fragments.
The proteasome consists of a barrel-shaped structure made up of several subunits. This cylindrical complex contains a central chamber where the protein substrates are degraded. The proteasomal degradation process is regulated at multiple levels and plays a crucial role in numerous cellular processes, including cell cycle progression, gene expression, protein quality control, and antigen presentation.
Overall, proteasomal degradation is a tightly regulated mechanism that ensures the removal of unwanted or damaged proteins from the cell. By selectively targeting specific proteins for degradation, it contributes to the maintenance of protein homeostasis and the overall health and functionality of the cell.
Common Misspellings for PROTEASOMAL DEGRADATION
- oroteasomal degradation
- lroteasomal degradation
- 0roteasomal degradation
- peoteasomal degradation
- pdoteasomal degradation
- pfoteasomal degradation
- ptoteasomal degradation
- p5oteasomal degradation
- p4oteasomal degradation
- priteasomal degradation
- prkteasomal degradation
- prlteasomal degradation
- prpteasomal degradation
- pr0teasomal degradation
- pr9teasomal degradation
- proreasomal degradation
- profeasomal degradation
- progeasomal degradation
- proyeasomal degradation
- pro6easomal degradation
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