TRANSPLANTATION TOLERANCE Meaning and
Definition
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Transplantation tolerance refers to a state in which an individual's immune system does not mount an immune response against a transplanted organ or tissue. It is a desirable outcome in organ transplantation as it allows for successful engraftment of the new organ without the need for lifelong immunosuppressive drugs.
In transplantation, the immune system recognizes the transplanted organ as foreign and activates an immune response to eliminate it. However, in cases of transplantation tolerance, the immune system is trained to recognize the transplanted organ as "self" instead of foreign. This leads to a state of immune tolerance, where the immune response is not activated, and the organ is not rejected.
There are different mechanisms by which transplantation tolerance can be achieved. These include central tolerance, where the immune system is educated during its development to recognize and tolerate self-antigens, and peripheral tolerance, mechanisms that actively suppress or regulate immune responses against transplanted tissues.
Transplantation tolerance can be induced through various approaches, such as mixed chimerism, where donor and recipient immune cells coexist in the recipient, leading to immune tolerance. Other strategies include the use of immunosuppressive drugs, regulatory T cells, or induction of immune tolerance through the manipulation of co-stimulatory molecules or regulatory pathways.
Overall, transplantation tolerance represents an important goal in transplantation medicine, as it holds the potential to minimize the complications associated with rejection and improve long-term graft survival.
Common Misspellings for TRANSPLANTATION TOLERANCE
- rransplantation tolerance
- fransplantation tolerance
- gransplantation tolerance
- yransplantation tolerance
- 6ransplantation tolerance
- 5ransplantation tolerance
- teansplantation tolerance
- tdansplantation tolerance
- tfansplantation tolerance
- ttansplantation tolerance
- t5ansplantation tolerance
- t4ansplantation tolerance
- trznsplantation tolerance
- trsnsplantation tolerance
- trwnsplantation tolerance
- trqnsplantation tolerance
- trabsplantation tolerance
- tramsplantation tolerance
- trajsplantation tolerance
- trahsplantation tolerance
Etymology of TRANSPLANTATION TOLERANCE
The word "transplantation" comes from the Latin word "transplantare", which is a combination of "trans" meaning "across" or "beyond", and "plantare" meaning "to plant". In this context, it refers to the relocation of an organ or tissue from one individual (the donor) to another (the recipient).
The word "tolerance" comes from the Latin word "tolerantia", meaning "endurance" or "forbearance". It is derived from the verb "tolerare", which means "to bear" or "to endure". In the context of transplantation, tolerance refers to the ability of the recipient's immune system to accept and not reject the transplanted organ or tissue.
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