HARMALINE Meaning and
Definition
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Harmaline is a naturally occurring alkaloid compound that belongs to the harmala alkaloids family. It is derived from the seeds of plants belonging to the Peganum genus, such as Peganum harmala, also known as Syrian rue. Harmaline is chemically classified as a beta-carboline and is structurally similar to harmine, another compound present in the same plant species.
Harmaline possesses various pharmacological properties and has been explored for its medicinal and psychoactive effects. It acts primarily as a reversible inhibitor of the enzyme monoamine oxidase, which plays a crucial role in the metabolism of neurotransmitters like serotonin, dopamine, and norepinephrine. By inhibiting this enzyme, harmaline leads to an increase in these neurotransmitters' concentrations, enhancing their effects and resulting in altered mood and cognition.
Harmaline is renowned for its role in traditional and religious ceremonies in different cultures worldwide. It has been used for centuries in spiritual practices, especially in shamanistic rituals and Ayahuasca brews. The compound's psychoactive properties can induce vivid hallucinations, altered states of consciousness, and introspective experiences. However, it is important to note that harmaline possesses potential toxic properties and should be used with caution.
In modern research, harmaline has also shown promising applications in neuroscience and medicine. Studies have demonstrated its neuroprotective properties and its potential use in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Additionally, harmaline has been investigated for its anti-inflammatory, antioxidant, and anticancer activities.
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An alkaloid, C13H14N2O, derived from the seeds of the wild rose (Peganum harmala), resembling quinine in its properties.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for HARMALINE
Etymology of HARMALINE
The word "Harmaline" is derived from the scientific name of the plant from which it is derived, Peganum harmala. Peganum harmala is a perennial flowering plant native to the Mediterranean region and certain areas of Asia. It has been historically used for various medicinal and ritualistic purposes by different cultures.
The term "harmaline" specifically refers to one of the alkaloids found in Peganum harmala, along with other related compounds such as harmine, harmalol, and harman. Alkaloids are a class of naturally occurring organic compounds known for their alkaline properties. Harmaline was first isolated and identified from the seeds of Peganum harmala in the mid-19th century.
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